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Reactiva-tion of edrophonium-inhibited enzyme occurs in< 10 min, and does not involve hydrolysis ofthe inhibitor, but only its diffusion—action is brief.The half-life of reactivation of carbamylatedenzyme (about 30 min) is less than that of synthesisof fresh enzyme protein, while that of phosphory-lated enzyme (in days) is more than the regene-ration time. Current smokers were more than twice as likely todevelop an infection (P=0.05) and 3.7 times as likely to develop osteomyelitis (P=0.01).Patients with multiple comorbidities are also at high risk for infection after open frac-ture. For example, the approximate survival rate at 6 months for cases is62%, and for controls, it is 78% (Figure 3.2), a difference of ?16 percentagepoints. Any dose not administered at the recommended age should be administered at a subsequent visit, whenindicated and feasible Any dose not administered at the recommended age should be administered at a subsequent visit, whenindicated and feasible. The most common means of induction is masking the patientdown with an inhalant (see Figure 7.7). Children were subse-quently tested for their ability to recall words anddraw inferences regarding the spoken material.Children performed better on both of these taskswhen listening to the normal voice.
Average bone-to-serum concentration ratiosincreased from 0.27 to 1.2 between 1 and 12h after the dose, suggesting slow redistributionfrom bone to blood.
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